Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic, Rochester, MN, USA. Electronic address: shen.xinming@mayo.edu. Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic, Rochester, MN, USA. Department of Child Neurology, Massachusetts General Hospital for Children, Lexington, MA, USA. Department of Physiology and Biomedical Engineering and Receptor Biology Laboratory, Mayo Clinic, Rochester, MN, USA; Department of Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA. Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic, Rochester, MN, USA. Electronic address: age@mayo.edu.